Search on: UBIQUITIN-PROTEIN LIGASES 
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Descriptor English:   Ubiquitin-Protein Ligases 
Descriptor Spanish:   Ubiquitina-Proteína Ligasas 
Descriptor Portuguese:   Ubiquitina-Proteína Ligases 
Synonyms English:   Ubiquitin-Protein Ligase  
Tree Number:   D08.811.464.938.750
Definition English:   A diverse class of enzymes that interact with UBIQUITIN-CONJUGATING ENZYMES and ubiquitination-specific protein substrates. Each member of this enzyme group has its own distinct specificity for a substrate and ubiquitin-conjugating enzyme. Ubiquitin-protein ligases exist as both monomeric proteins multiprotein complexes. 
Indexing Annotation English:   UBIQUITIN-PROTEIN LIGASE COMPLEXES is also available
History Note English:   2004; use UBIQUITIN-PROTEIN LIGASE (NM) 1983-2003 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
CT contraindications DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   38183 
Unique Identifier:   D044767 

Occurrence in VHL: 		 

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